basis of biosurgery
Why do Phaenicia sericata produce substances that cause healing of wounds?
Larvae of this Diptera species belong to an obligatory group of parasites (feeding on the living tissue of its host) causing myiazis in mammals and birds. Following the evolutional changes of Phaenicia’s feeding habits (Stevens &Wall 1997, Stevens 2003) we can single out three groups: saprofagi which feed on still organic matter, facultative ectoparasites which can partially feed on still tissue as well as on living cells and finally obligatory parasites which feed exclusively on tissue of living vertebrates. In conclusion, development of obligatory parasites is fully dependent on health of their hosts.
Since it is a mandatory requirement for that particular species to maintain its host’s health intact, in order to complete a full reproductive cycle which lasts about 25 days, therefore wounds into which greenbottle fly lays its eggs must in short time be fully recovered which in turn greatly increases chances of successful full reproductive cycle. This clearly explains why larvae of this particular parasite possess a whole range of biologically active substances that initiate and facilitate a brisk healing process.
During the co evolutionary process of parasite and host in the last 200 min years ectoparsitic flies have developed bacteristatic factors such as Lucifensins that sterilize wounds, enzymes which digest still kolegene fibers and facilitate the healing process as well as cell growth and proliferation factors allowing for regeneration of targeted tissue. These factors dramatically increase the chances of host’s survival. This phenomena has allowed for creation of modern biomaterial which is an extremely effective therapy in clinical cases in humans.