for doctors

Scientific
basis of biosurgery

Why do Phaenicia sericata produce substances that cause healing of wounds?

Larvae of this Diptera species belong to an obligatory group of  parasites (feeding on the living tissue of its host)  causing  myiazis in mammals and  birds.  Following the evolutional changes of  Phaenicia’s  feeding habits (Stevens &Wall 1997, Stevens 2003) we can single out three groups: saprofagi which feed on still organic matter, facultative ectoparasites which can partially  feed on still tissue as well as on living cells and finally obligatory parasites which feed exclusively  on tissue of living vertebrates. In conclusion, development of obligatory parasites is fully dependent on health of their hosts. 

Since  it is a mandatory requirement for that particular species  to maintain its host’s health intact,  in order to complete a full reproductive cycle  which lasts about 25 days, therefore wounds into which  greenbottle fly lays its  eggs must in short time be fully recovered which in turn greatly increases chances of successful  full reproductive cycle. This clearly  explains why larvae of this particular parasite possess a whole range of biologically active substances that  initiate and facilitate a brisk healing process. 

During the co evolutionary process of parasite and host in the last 200 min years  ectoparsitic flies have developed bacteristatic factors such as Lucifensins that sterilize wounds, enzymes which digest still kolegene fibers and facilitate the  healing process as well as cell growth and  proliferation factors allowing for regeneration of  targeted tissue. These factors dramatically increase the chances of host’s survival. This phenomena has allowed  for creation of modern biomaterial  which is an extremely effective therapy in clinical cases in humans.


 

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