In the Sherman (2003) study of 18 diabetes patients with 20 nonhealing neuropathic foot and leg wounds treated with maggot therapy and standard medical and surgical therapy indicated that debridement of still tissue by means of maggot therapy was significantly more effective and efficient than in conventional medical and surgical method(p=0.02). Biosurgical therapy caused faster granulation of tissue (p=0.016) and wound epithelialization just after four weeks(p=0.018).
Other studies show a high efficiency in treatment of ulcers in diabetic foot cases and especially neuropatic ones. Other researches still show great efficacy in extreme cases where maintaining the foot is at stake. 40-50% amputation cases have been avoided and resulted in full recovery.